Join us to make history

Responsibilities

• 协助研发部主任制定研发计划、时间节点及里程碑；
• 解决研发过程中出现的问题，保障研发计划的推进；
• 向上级领导汇报项目进展，对研发人员提供技术培训。

Requirements

• 细胞/分子生物学、转录/表观遗传学、合成生物学、基因组学等相关专业博士学历；
• 有雄厚的细胞/分子生物学方面的专业知识和相关研究经历；
• 三年以上工作经验，有生物医药企业工作经历，具有项目管理经验优先考虑（优秀者条件可放宽）；
• 团队合作精神和良好的交流沟通能力，包括英文沟通能力。

Responsibilities

• 负责小核酸药物临床前的药效、药代、毒理、安全性评价等相关研究；
• 负责公司内部药效、毒理实验设计、实施，分析总结实验数据，撰写实验报告；
• 执行小动物实验，包括建立肿瘤模型（肿瘤皮下和原位种植）、给药、测量、数据分析等；
• 完成部门主管交待的其它实验室相关任务。

Requirements

• 生物医学相关本科或者以上学历；
• 具有良好的细胞生物学、动物学及临床前研究背景；
• 有建立各种动物模型特别是肿瘤模型经验者优先考虑；
• 熟练掌握各种小动物操作（静脉给药等）、细胞培养、组织病理、核酸提取、mRNA及蛋白表达分析、流式细胞分析等技术；
• 动手能力强、学习新技术快、认真负责、积极主动、耐心细致、踏实肯干；
• 良好的沟通能力和团队合作精神。

Responsibilities

Ractigen Therapeutics, founded by the pioneers of a paradigm-shifting technology known as RNAa, is the leading RNAa-based pharmaceutical company, located in a modern biotech industry park of Nantong City of Jiangsu Province (2 h drive from Shanghai), China. We are seeking highly motivated and creative talents at all career levels with the qualifications specified below to join an international team of scientists to brining into market ground-breaking medicines for many severely unmet clinical needs. Particularly, we welcome qualified individuals from within and outside of China to apply.

The positions to be filled are:

• Director/Principal Scientist/Senior Scientist/Scientist, Cell/molecular biology, HTS and lead discovery/optimization
• Principal Scientist/Senior Scientist/Scientist, Oncology/immuno-oncology, genetic diseases
• Senior Director/Director/Principal Scientist, in vivo and/or in vitro Pharmacology, ADME/DMPK
• Director/Principal Scientist/Senior Scientist, in Medicinal chemistry/nucleic acid chemistry, formulation development for oligonucleotide delivery (lipid nanoparticle- and conjugation-based)

Benefits:

• Working in a stimulating environment and with an international team of scientists and entrepreneurs;
• Excellent physical working environment with recreation area and equipment
• Free/subsidized housing;
• Internationally competitive salaries with a generous benefit package including bonus and stock options;
• Talent incentives provided by local governments and competitive talent programs for qualified individuals.
• Unique experience of working in China, and particularly in Yangtze River Delta Economic Zone which is poised to become the World’s epic center for drug development.

Requirements

• Ph.D./M.D. in life sciences with Postdoc, or MS in life science with minimum 5+ years of relevant experience and distinguished publication record;
• The candidates should have a solid background in one of the following areas: cell/molecular biology, oncology and immune-oncology, nucleic acid/oligonucleotide chemistry, oligonucleotide-based drug development, oligonucleotide formulation development, IND-enabling development of oligonucleotide drugs;
• You are willing to lead and orchestrate a group of scientists with diverse expertise in a multidisciplinary drug discovery program;
• You have previous experience in oligonucleotide drug discovery from hit identification to lead optimization and pre-clinical studies;
• You have a strong experience in a biotechnology or pharmaceutical environment;
• You are science-driven, result-oriented, and should demonstrate technical proficiency, scientific creativity;
• You should demonstrate collaboration/team spirit and excellent verbal and written communication skills (English);
• Track record of scientific success demonstrated by authorship on publications in excellent journals, and/ or patents.

Responsibilities

全面负责公司在研新药项目中国、美国申报的临床前评价及IND工作,包括但不限于制定计划、设立目标、组织团队并实施计划，协调各方面关系，包括供应商、CMO、CRO等，确保项目按计划推进和达成既定目标，具体包括：

1. 根据公司战略目标，制定、领导和执行非临床IND开发计划。
2. 制定所负责项目的预算，控制并调节试验费用开支。
3. 为所负责开发项目制定里程碑、时间节点及工作流程，确保按期完成里程碑事件和工作目标。
4. 协助临床前开发部门在先导化合物开发及作用机制研究方面的工作。
5. 负责公司内部的药效及毒理研究。
6. 负责外部合作方包括原料（制剂）供应商、CMO、CRO等的选择、审查和管理，包括询价、价格估算等；负责在项目实施过程中与各合作方的沟通协调，发现并解决问题，确保各项外包工作的质量和进度。
7. 负责IND申报所需的各项体外研究及临床前研究计划制定、实施和数据准备和申报工作。
8. 负责与监管部门的各项沟通工作，包括药理、毒理及其他pre-IND及IND过程。
9. 参与临床试验方案的制定，确保所负责项目向临床开发阶段的顺利推进。

Requirements

1. 生物医学、药学相关博士学位，5年以上相关工作经验，负责过至少两个创新药的临床申报工作。
2. 熟悉药物研发过程，熟悉中国、美国IND法规要求，有双报经验者优先。
3. 具备优秀的领导、决策和判断能力，良好的管理能力和沟通能力。
4. 有国际制药公司或CRO公司相关工作经验者优先。
5. 具有小核酸药物开发经验者优先
6. 良好的英文口语及书面交流能力。

Responsibilities

全面负责公司在研新药项目中国、美国申报的临床前评价及IND工作,包括但不限于制定计划、设立目标、组织团队并实施计划，协调各方面关系，包括供应商、CMO、CRO等，确保项目按计划推进和达成既定目标，具体包括：

1. 根据公司战略目标，制定、领导和执行非临床IND开发计划。

2. 制定所负责项目的预算，控制并调节试验费用开支。

3. 为所负责开发项目制定里程碑、时间节点及工作流程，确保按期完成里程碑事件和工作目标。

4. 协助临床前开发部门在先导化合物开发及作用机制研究方面的工作。

5. 负责公司内部的药效及毒理研究。

6. 负责外部合作方包括原料（制剂）供应商、CMO、CRO等的选择、审查和管理，包括询价、价格估算等；负责在项目实施过程中与各合作方的沟通协调，发现并解决问题，确保各项外包工作的质量和进度。

7. 负责IND申报所需的各项体外研究及临床前研究计划制定、实施和数据准备和申报工作。

8. 负责与监管部门的各项沟通工作，包括药理、毒理及其他pre-IND及IND过程。

9. 参与临床试验方案的制定，确保所负责项目向临床开发阶段的顺利推进。

Requirements

1. 生物医学、药学相关博士学位，5年以上相关工作经验，负责过至少两个创新药的临床申报工作。

2. 熟悉药物研发过程，熟悉中国、美国IND法规要求，有双报经验者优先。

3. 具备优秀的领导、决策和判断能力，良好的管理能力和沟通能力。

4. 有国际制药公司或CRO公司相关工作经验者优先。

5. 具有小核酸药物开发经验者优先

6. 良好的英文口语及书面交流能力。

Responsibilities

Ractigen Therapeutics, founded by the pioneers of a paradigm-shifting technology known as RNAa, is the leading RNAa-based pharmaceutical company, located in a modern biotech industry park of Nantong City of Jiangsu Province (2 h drive from Shanghai), China. We are seeking highly motivated and creative talents at all career levels with the qualifications specified below to join an international team of scientists to brining into market ground-breaking medicines for many severely unmet clinical needs. Particularly, we welcome qualified individuals from within and outside of China to apply.

The positions to be filled are:

• Director/Principal Scientist/Senior Scientist/Scientist, Cell/molecular biology, HTS and lead discovery/optimization
• Principal Scientist/Senior Scientist/Scientist, Oncology/immuno-oncology, genetic diseases
• Senior Director/Director/Principal Scientist, in vivo and/or in vitro Pharmacology, ADME/DMPK
• Director/Principal Scientist/Senior Scientist, in Medicinal chemistry/nucleic acid chemistry, formulation development for oligonucleotide delivery (lipid nanoparticle- and conjugation-based)

Benefits:

• Working in a stimulating environment and with an international team of scientists and entrepreneurs;
• Excellent physical working environment with recreation area and equipment
• Free/subsidized housing;
• Internationally competitive salaries with a generous benefit package including bonus and stock options;
• Talent incentives provided by local governments and competitive talent programs for qualified individuals.
• Unique experience of working in China, and particularly in Yangtze River Delta Economic Zone which is poised to become the World’s epic center for drug development.

Requirements

• Ph.D./M.D. in life sciences with Postdoc, or MS in life science with minimum 5+ years of relevant experience and distinguished publication record;
• The candidates should have a solid background in one of the following areas: cell/molecular biology, oncology and immune-oncology, nucleic acid/oligonucleotide chemistry, oligonucleotide-based drug development, oligonucleotide formulation development, IND-enabling development of oligonucleotide drugs;
• You are willing to lead and orchestrate a group of scientists with diverse expertise in a multidisciplinary drug discovery program;
• You have previous experience in oligonucleotide drug discovery from hit identification to lead optimization and pre-clinical studies;
• You have a strong experience in a biotechnology or pharmaceutical environment;
• You are science-driven, result-oriented, and should demonstrate technical proficiency, scientific creativity;
• You should demonstrate collaboration/team spirit and excellent verbal and written communication skills (English);
• Track record of scientific success demonstrated by authorship on publications in excellent journals, and/ or patents.

Responsibilities

1. Perform animal experiments and some other experiments arranged by the supervisor.
2. Establish tumor animal models (subcutaneous implantation).
3. Perform drug administration, measurement and data analysis.
 

Requirements

1. Master degree or above in biomedical science.
2. Experience of cell biology, zoology and preclinical studies.
3. Experience of establishing various animal models especially tumor animal models is preferred.
4. Skilled in animal experiments such as intravenous administration, cell culture, histopathology, nucleic acid isolation, mRNA/protein expression analysis and FACS.
5. Excellent communication and learning skills, strong responsibility, practical capacity and teamwork spirit.
 

Responsibilities

1. Perform basic experiments such as cell culture, nucleic acid isolation and gel electrophoresis.  
2. Purchase experimental reagents and supplies, and do QC testing for the reagents.
3. Assist the supervisor in drafting laboratory SOPs related to security and some other aspects.
 

Requirements

1. Bachelor degree or above in biology or medical science. Experience of biological laboratory management is preferred.
2. Familiar with laboratory equipment, reagents and supplies.
3. Skills of basic biology experimental skills such as aseptic technique, cell culture, nucleic acid isolation and gel electrophoresis.  
4. Good English especially speaking and reading. 
5. Strong responsibility, professionalism, coordination and practical capacity.
6. Efficient use of software systems is preferred.   
 

Responsibilities

1. Perform primary cell culture and make the cell lines stably passage. 
2. Do high throughput RNAi screening (HTS) based on lentivirus and some other HTS. 
3. Perform transfection, vector construction, molecular cloning, mRNA/gene expression analysis and FACS.
4. Participate in projects related to discovery and validation of saRNA candidates. 
 

Requirements

1. Master degree or above in biomedical science; with experience of research on cell/molecular biology.
2. Skilled in transfection, vector construction, molecular cloning, mRNA/gene expression analysis and FACS.
3. Spirit of adventure, innovation and teamwork. 
4. Excellent communication and learning skills, as well as good compressive capacity.
 

Responsibilities

1. Perform molecular design and optimization for saRNA gene activation systems. 
2. Establish high throughput RNAi screening systems based on lentivirus and new high throughput screening (HTS) systems based on shRNA. 
3. Analyze and design various nucleic acid and protein sequences.
 

Requirements

1. Master's degree in biomedical science. Postdoctoral experience of cell/molecular biology, synthetic biology or transcription/epigenetic regulation is preferred.
2. Skilled in molecular cloning, report gene analysis, cell culture, RNA technology, nucleic acid isolation, and mRNA/protein expression analysis. 
3. Spirit of adventure, innovation and teamwork. 
4. Excellent communication and learning skills, as well as good compressive capacity.
 

Responsibilities

Develop oligonucleotide delivery systems, including design, implementation, validation and optimization.

Requirements

1. Master degree or above in pharmaceutical preparation or pharmaceutical engineering
2. Over 2 years' preparation R&D experience.
3. Experience with developing nucleic acid delivery systems such as liposomes and nanoparticles is a plus.
4. Good knowledge of drug delivery system research process and approaches.
5. Knowledge of international small nucleic acid therapeutics.
 

Responsibilities

• Be responsible for setting up and running an oligonucleotide chemistry facility.
• Lead a team of scientists to provide oligonucleotide synthesis, chemical modification and purification for internal testing.
• Develop novel medicinal nucleic acid chemistry, conjugates and formulations.
• Be responsible for setting up and running an oligonucleotide chemistry facility.
• Lead a team of scientists to provide oligonucleotide synthesis, chemical modification and purification for internal testing.
• Develop novel medicinal nucleic acid chemistry, conjugates and formulations.

Requirements

• MS or PhD in Organic Chemistry.
• 2-5 years’ experience in academia or industry with nucleotide chemistry.
• Previous experience in oligonucleotide drug discovery from hit identification to lead optimization and pre-clinical studies.
• Experience with nucleotide, and solid-phase oligonucleotide synthesis.
• Experience preparing peptide conjugates of oligonucleotides.
• Proficient in the use of methods of instrumental chemical analysis, such as NMR, HPLC, MS, FTIR, is essential.
• Demonstrated ability to plan and execute independent and collaborative research projects.
• Co-authorship on one or more publications in peer-reviewed scientific journals.

Responsibilities

1. Assist Director of R&D in making project plans.
2. Troubleshoot during R&D to make the projects move forward as planned. 
3. Report project progress to the supervisor.
4. Provide technical training to technicians.
 

Requirements

1. PhD degree in cell/molecular biology, transcriptional/ apparent genetics, synthetic biology or genomics.
2. Good knowledge of cell/molecular biology and relevant research experience.
3. Over 3 years’ working experience. Experience with bio-pharmaceutical company or in project management is preferred. 
4. Fluent in English, communicative and collaborative mindset.
 

Responsibilities

to be updated

Requirements

to be updated

Responsibilities

1. Assist the supervisor in establishing nucleic acid synthesis, conjugation and purification systems.
2. Assist the supervisor in creating methods of nucleic acid modification and conjugation. 
3. Perform nucleic acid and peptide synthesis, modification, conjugation, isolation and purification as well as structural identification. 

Requirements

1. Master degree or above in nucleic acid chemistry or chemical biology. 
2. Over 2 years' relevant working experience.
3. Skilled in nucleic acid synthesis, modification, conjugation and purification. 
4. Team spirit, professionalism and innovative spirit.
5. Good English and ability to work independently.